Arsenic
Anticipatory
Do you know how to
differentiate between arsenic poisoning and chotera?
Objective
- To be able to define the Arsenical syndrome.
- To differentiate between arsenic poisoning and cholera infection.
- To differentiate between acute and chronic cases.
- To differentiate between arsenic poisoning and cholera infection.
- To differentiate between acute and chronic cases.
Instructional content.
Arsenical compounds present as contaminants of well water so arsenic toxicity can appear as mass toxicity in some areas.
*Microorganisms in the environment convert arsenic to dimethylarsenate that accumulate in the fish and providing a source of human exposure.
Arsenic is a general protoplasmic poison. It combines to SH-containing enezymes essential for tissue oxidation-reduction process.
In acute poisoning:
Symptoms:
Vomiting with watery bloody diarrhoea ( rice water stools) that not respond to the ordinary medical tratment.
Severe abdominal pain and burning in the mouth.
Signs;
- Differentiate the case from cholera mainly by painless diarrhoea then vomiting in cholera.
- In chronic poisoning
Symptoms
- Anorexia , diarrheoea alternating with constipation.
Signs;
- Skin lesion.
Hyperkeratosis of the palms and soles
Rain drop appearance in the palms
Painful arsenical warts in the extremities that are precancerous lesions and leading to gangrene of the extremities.
- Mucous membrane: corza-like manifestation: cough, lacrimation, hoarsness of voice and perforation of nasal septum.
- Peripheral neuritis: mixed (motor and sensory) but more sensory.
- Parenchymatous degeneration: fatty liver and jaundice, heart failure or renal failure.
Post mortem picture:
- Red velvety appearance of the stomach due to bleeding at the top ridges of the mucusal folds and white powder of arsenic sticking to gastric mucosa.
*Microorganisms in the environment convert arsenic to dimethylarsenate that accumulate in the fish and providing a source of human exposure.
Arsenic is a general protoplasmic poison. It combines to SH-containing enezymes essential for tissue oxidation-reduction process.
In acute poisoning:
Symptoms:
Vomiting with watery bloody diarrhoea ( rice water stools) that not respond to the ordinary medical tratment.
Severe abdominal pain and burning in the mouth.
Signs;
- Differentiate the case from cholera mainly by painless diarrhoea then vomiting in cholera.
- In chronic poisoning
Symptoms
- Anorexia , diarrheoea alternating with constipation.
Signs;
- Skin lesion.
Hyperkeratosis of the palms and soles
Rain drop appearance in the palms
Painful arsenical warts in the extremities that are precancerous lesions and leading to gangrene of the extremities.
- Mucous membrane: corza-like manifestation: cough, lacrimation, hoarsness of voice and perforation of nasal septum.
- Peripheral neuritis: mixed (motor and sensory) but more sensory.
- Parenchymatous degeneration: fatty liver and jaundice, heart failure or renal failure.
Post mortem picture:
- Red velvety appearance of the stomach due to bleeding at the top ridges of the mucusal folds and white powder of arsenic sticking to gastric mucosa.
Multi-choiceColoration of the gum is absent in cases of chronic poisoning with;
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Arsenic.
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Lead.
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Cadmium.
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Mercury.
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Bismuth.
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Black foot disease is a manifestation of chronic toxicity by:
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Inorganic arsenic salts
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Lead.
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Cadmium.
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Mercury.
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Transition:
Lead toxicity